You should not use Zoloft if you also take pimozide, or if you are being treated with methylene blue injection.

Do not use Zoloft if you have used an MAO inhibitor in the past 14 days, such as isocarboxazid, linezolid, methylene blue injection, phenelzine, rasagiline, selegiline, or tranylcypromine.

Some young people have thoughts about suicide when first taking an antidepressant. Stay alert to changes in your mood or symptoms. Report any new or worsening symptoms to your doctor.

Seek medical attention right away if you have symptoms of serotonin syndrome, such as: agitation, hallucinations, fever, sweating, shivering, fast heart rate, muscle stiffness, twitching, loss of coordination, nausea, vomiting, or diarrhea.

You should not use Zoloft if you are allergic to sertraline, or if you also take pimozide. Do not use the liquid form of Zoloft if you are taking disulfiram (Antabuse) or you could have a severe reaction to the disulfiram.

Do not take Zoloft within 14 days before or 14 days after you take an MAO inhibitor. A dangerous drug interaction could occur. MAO inhibitors include isocarboxazid, linezolid, phenelzine, rasagiline, selegiline, and tranylcypromine.

To make sure Zoloft is safe for you, tell your doctor if you have ever had:

• heart disease, high blood pressure, or a stroke;

• liver or kidney disease;

• a seizure;

• bleeding problems, or if you take warfarin (Coumadin, Jantoven);

• bipolar disorder (manic depression); or

• low levels of sodium in your blood.

Some medicines can interact with sertraline and cause a serious condition called serotonin syndrome. Be sure your doctor knows if you also take stimulant medicine, opioid medicine, herbal products, other antidepressants, or medicine for mental illness, Parkinson's disease, migraine headaches, serious infections, or prevention of nausea and vomiting. Ask your doctor before making any changes in how or when you take your medications.

Some young people have thoughts about suicide when first taking an antidepressant. Your doctor should check your progress at regular visits. Your family or other caregivers should also be alert to changes in your mood or symptoms.

Get emergency medical help if you have signs of an allergic reaction to Zoloft: skin rash or hives (with or without fever or joint pain); difficulty breathing; swelling of your face, lips, tongue, or throat.

Report any new or worsening symptoms to your doctor, such as: mood or behavior changes, anxiety, panic attacks, trouble sleeping, or if you feel impulsive, irritable, agitated, hostile, aggressive, restless, hyperactive (mentally or physically), more depressed, or have thoughts about suicide or hurting yourself.

Call your doctor at once if you have:

• a seizure (convulsions);

• blurred vision, tunnel vision, eye pain or swelling;

• low levels of sodium in the body - headache, confusion, memory problems, severe weakness, feeling unsteady; or

• manic episodes - racing thoughts, increased energy, unusual risk-taking behavior, extreme happiness, being irritable or talkative.

Seek medical attention right away if you have symptoms of serotonin syndrome, such as: agitation, hallucinations, fever, sweating, shivering, fast heart rate, muscle stiffness, twitching, loss of coordination, nausea, vomiting, or diarrhea.

Common Zoloft side effects may include:

• drowsiness, tiredness, feeling dizziness, anxious or agitated;

• indigestion, nausea, diarrhea, loss of appetite;

• sweating;

• tremors or shaking;

• sleep problems (insomnia); or

• decreased sex drive, impotence, or difficulty having an orgasm.