You should not take Wellbutrin XL if you have seizures or an eating disorder, or if you have suddenly stopped using alcohol, seizure medication, or sedatives. If you take Wellbutrin for depression, do not also take Zyban to quit smoking.

Do not use Wellbutrin XL within 14 days before or 14 days after you have used an MAO inhibitor, such as isocarboxazid, linezolid, methylene blue injection, phenelzine, rasagiline, selegiline, or tranylcypromine.

Some young people have thoughts about suicide when first taking an antidepressant. Stay alert to changes in your mood or symptoms. Report any new or worsening symptoms to your doctor.

You should not take Wellbutrin XL if you are allergic to it, or if you have:

• a seizure disorder;

• an eating disorder such as anorexia or bulimia; or

• if you have suddenly stopped using alcohol, seizure medication, or a sedative such as Xanax, Valium, Fiorinal, Klonopin, and others).

Do not use an MAO inhibitor within 14 days before or 14 days after you take Wellbutrin XL. A dangerous drug interaction could occur. MAO inhibitors include isocarboxazid, linezolid, phenelzine, rasagiline, selegiline, and tranylcypromine.

Do not take Wellbutrin XL to treat more than one condition at a time. If you take this medicine for depression, do not also take Wellbutrin XL to quit smoking.

Wellbutrin XL may cause seizures, especially if you have certain medical conditions or use certain drugs. Tell your doctor about all of your medical conditions and the drugs you use.

To make sure Wellbutrin XL is safe for you, tell your doctor if you have:

• a history of head injury, seizures, or brain or spinal cord tumor;

• narrow-angle glaucoma;

• heart disease, high blood pressure, history of heart attack;

• diabetes;

• kidney or liver disease (especially cirrhosis);

• bipolar disorder or other mental illness; or

• if you drink alcohol.

Some young people have thoughts about suicide when first taking an antidepressant. Your doctor will need to check your progress at regular visits. Your family or other caregivers should also be alert to changes in your mood or symptoms.

It is not known whether this medicine will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant.

Bupropion can pass into breast milk and may harm a nursing baby. You should not breast-feed while using this medicine.

Wellbutrin XL is not approved for use by anyone younger than 18 years old.

Get emergency medical help if you have signs of an allergic reaction: hives, rash or itching; fever, swollen glands, joint pain, general ill feeling; difficult breathing; swelling of your face, lips, tongue, or throat.

Report any new or worsening symptoms to your doctor, such as: mood or behavior changes, anxiety, depression, panic attacks, trouble sleeping, or if you feel impulsive, irritable, agitated, hostile, aggressive, restless, hyperactive (mentally or physically), or have thoughts about suicide or hurting yourself.

Call your doctor at once if you have:

• a seizure (convulsions);

• unusual changes in mood or behavior;

• a manic episode--racing thoughts, increased energy, reckless behavior, feeling extremely happy or irritable, talking more than usual, severe problems with sleep;

• blurred vision, tunnel vision, eye pain or swelling, or seeing halos around lights;

• fast heartbeats; or

• severe skin reaction--fever, sore throat, swelling in your face or tongue, burning in your eyes, skin pain, followed by a red or purple skin rash that spreads (especially in the face or upper body) and causes blistering and peeling.

Common side effects may include:

• dry mouth, stuffy nose;

• nausea, constipation;

• sleep problems (insomnia);

• feeling anxious;

• dizziness; or

• joint pain.